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Ribosomal frameshifting in pfizer injectables

R. Kingi made this Official Information request to Ministry of Health

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From: R. Kingi

Dear Ministry of Health,

Recently there has been publication of an article detailing so called ribosomal frameshifting in products that incorperate N1-methylpseudouridine into the modified mRNA, e.g. the pfizer covid vaccine.

https://www.nature.com/articles/s41586-0...

This concern was raised in 2021 so obviously it is a risk that competent scientists could flag, however it was largely ignored at the time.

Please detail all internal communications around frameshifting as a potential risk, or area of reasonable concern. If it was not considered a potential risk, please detail internal communications that lead to it being dismissed as a risk, and how that conclusion was drawn.

Yours faithfully,

R. Kingi

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Kia ora
  
Thank you for your request for official information. The reference number
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Ngā mihi
 
OIA Services Team
Manatū Hauora | Ministry of Health
M[4]inistry of Health information releases 
 
 

------------------- Original Message -------------------
From: R. Kingi <[FOI #25103 email]>;
Received: Sat Dec 09 2023 15:12:33 GMT+1300 (New Zealand Daylight Time)
To: OIA Requests <[email address]>; OIA <[email address]>;
Subject: Official Information request - Ribosomal frameshifting in pfizer
injectables

Dear Ministry of Health,

Recently there has been publication of an article detailing so called
ribosomal frameshifting in products that incorperate
N1-methylpseudouridine into the modified mRNA, e.g. the pfizer covid
vaccine.

[5]https://aus01.safelinks.protection.outlo...

This concern was raised in 2021 so obviously it is a risk that competent
scientists could flag, however it was largely ignored at the time.

Please detail all internal communications around frameshifting as a
potential risk, or area of reasonable concern. If it was not considered a
potential risk, please detail internal communications that lead to it
being dismissed as a risk, and how that conclusion was drawn.

Yours faithfully,

R. Kingi
 

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If you are not the intended recipient, do not read, use, disseminate,
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References

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1. http://www.ombudsman.parliament.nz/
2. mailto:[email address]
3. mailto:[email address]
4. https://www.health.govt.nz/about-ministr...
5. https://www.nature.com/articles/s41586-0...

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From: OIA Requests


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Kia ora
Please find attached a letter rearing your request for information

Ngā mihi 

  

OIA Services Team

Manatū Hauora | Ministry of Health

M[1]inistry of Health information releases 
U[2]nite against COVID-19 

****************************************************************************
Statement of confidentiality: This e-mail message and any accompanying
attachments may contain information that is IN-CONFIDENCE and subject to
legal privilege.
If you are not the intended recipient, do not read, use, disseminate,
distribute or copy this message or attachments.
If you have received this message in error, please notify the sender
immediately and delete this message.
****************************************************************************

References

Visible links
1. https://www.health.govt.nz/about-ministr...
2. https://covid19.govt.nz/

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