Kia ora Erika

 

Thank you for your request under the Official Information Act 1982 (the
Act), received by the Ministry of Health on 25 October 2025. You
requested:
 

The non clinical report for the Pfizer Covid vaccine  talks about T cells
declining relatively quickly after 5 weeks after the second dose on page
31 of this report:

https://www.health.govt.nz/system/files/...

It says “ Please comment on these findings in relation to the potential of
the vaccine for antibody-dependent disease enhancement (ADE) and
vaccine-associated enhanced respiratory disease (VAERD)”

The response in the report to this is….
“ In the ongoing Phase 1 studies in the US and Germany (C4591001 and
BNT162-01, respectively), persistence of antibody and T cell responses are
being assessed up to 2 years following vaccination and will provide the
most relevant and reliable measure of long-term memory.”

Please share the report C4591001 which contains the results of the
persistence of antibody and T cell responses following vaccinations.

Given this non clinical report was sent to medsafe January 2021, it’s been
more than 2 years so I would expect C4591001 to be well completed .
 

The reference number for your request is H2025074646. As required under
the Act, the Ministry will endeavour to respond to your request no later
than 20 working days after the day your request was
received: [1]http://www.ombudsman.parliament.nz/

 

If you have any queries related to this request, please do not hesitate to
get in touch ([2][email address]).

 

 

Ngâ mihi 
 
  

OIA Services Team

Ministry of Health  | Manatû Hauora 

M[3]inistry of Health information releases 

 

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References

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1. http://www.ombudsman.parliament.nz/
2. mailto:[email address]
3. https://www.health.govt.nz/about-ministr...

Tēnā koe Erika 

 

Thank you for your request under the Official Information Act 1982 (the
Act) to the Ministry of Health – Manatū Hauora (the Ministry) on 25
October 2025 asking: 

 

“...Please share the report C4591001 which contains the results of the
persistence of antibody and T cell responses following vaccinations.” 

 

This information is publicly available at the following link:
[1]www.pfizer.com/sites/default/files/plsr-studies/C4591001%20Plain%20Language%20Study%20Results%20Summary%20%28PLSRS%29%20Phase%202-4.pdf.
Therefore, your request is refused under section 18(d) of the Act. 

 

I trust this information fulfils your request.  If you wish to discuss any
aspect of your request with us, including this decision, please feel free
to contact the OIA Services Team on: [2][email address].  

 

Under section 28(3) of the Act, you have the right to ask the Ombudsman to
review any decisions made under this request. The Ombudsman may be
contacted by email at: [3][email address] or by calling 0800
802 602. 

 

Ngā mihi 

  

OIA Services Team

Ministry of Health  | Manatū Hauora 

M[4]inistry of Health information releases 

 

show quoted sections

References

Visible links
1. https://www.pfizer.com/sites/default/fil...
2. mailto:[email address]
3. mailto:[email address]
4. https://www.health.govt.nz/about-ministr...